Addressing the Unmet Needs of Patients With Moderate to Severe Psoriasis
A Visual Exploration of Disease Pathogenesis and the Clinical Potential of Targeting the TYK2 Pathway as a Novel Non-Biologic Oral Therapeutic Option
Psoriasis is a chronic immune-mediated disorder that impairs patients’ physical health, quality of life, and work productivity. Almost one-fifth of affected
persons have moderate to severe disease, with extensive skin involvement affecting at least 3% of the body surface area. Systemic treatments are usually
administered to patients with moderate to severe disease. Despite available oral and injectable treatments for psoriasis, additional oral treatments could be
The Janus Kinase–Signal Transducer and Activator of Transcription (JAK–STAT) pathway plays a significant role in intracellular signaling of cytokines of
numerous cellular processes, important in both normal and pathological states of immune-mediated inflammatory diseases. Particularly in psoriasis, where the
interleukin (IL)-23/IL-17 axis is currently considered the crucial pathogenic pathway, blocking the JAK/STAT pathway with small molecules would be expected
to be clinically effective. However, relative nonspecificity and low therapeutic index of the available JAK inhibitors have delayed their integration into the
therapeutic armamentarium of psoriasis. Thus, current research has shifted focus to Tyrosine kinase 2 (TYK2), the first described member of the JAK family.
In these PeerView regional meetings, our experts will offer insight into the complex pathogenesis that underlies psoriasis and other inflammatory autoimmune
conditions, focusing on the rationale for TYK2 inhibition as a therapeutic strategy. In addition, key information (eg, selectivity, side-effect profiles, dosing) for
kinase inhibitors in development that are targeting the TYK2 pathway for the treatment of psoriasis will be provided, as well as the most up-to-date clinical trial
Upon completion of this activity, participants should be better able to:
- Explain the role of the JAK/STAT signaling pathway in the pathophysiology of psoriasis
- Summarize efficacy and safety data related to current and emerging kinase inhibitors for the treatment of psoriasis
- Treat moderate to severe psoriasis in accordance with current evidence and guidelines, recognizing the role of non-biologic therapies in addressing the
burden of disease and comorbidities in individual patients
Providership, Credit, and Support
Physician Continuing Medical Education:
Medical Learning Institute, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical
education for physicians.
The Medical Learning Institute, Inc. designates this live activity for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit
commensurate with the extent of their participation in the activity.
This activity is developed with our educational partner, PVI, PeerView Institute for Medical Education.
This activity is supported through an educational grant from Bristol Myers Squibb.